This study considers the potential regional economic gains in Pennsylvania from advanced biofuels production. The analysis considers four producing regions and, respectively, miscanthus, switchgrass, and soft willow as the cellulosic feedstocks. In all, 12 models were developed to project economic impacts in each region and for each feedstock type. The modeling process combined inputs from Penn State experts in crop production, the transformation of that information so that it was suitable for entry into an impact modeling structure, technical production coefficients from the National Renewable Energy Laboratories (NREL) for enzymatic cellulosic ethanol production, and regionally-specific industrial production accounts generated from the IMPLAN input-output modeling system.